A spray granulation production method for chlorine-based compound fertilizer comprises the following steps: according to the required structure for compound fertilizer, appropriate ammonium sulfate, potassium chloride, ammonium diacid phosphate, filling agent and phosphate are adopted in proportion to prepare a liquid mixed acid, fully stirred and evenly mixed; then the liquid mixed acid is conveyed into a pipe-type reactor, ammonia gas is introduced into the pipe-type reactor for neutralization reaction, and slurry with the viscosity is formed after reaction of the liquid mixed acid and ammonia gas; the slurry is sprayed into a granulating machine for granulation through a spraying gun; and then a finished product is obtained after the processes of drying and cooling. The chlorine-based compound fertilizer prepared by the method has the advantages of smooth grains, high intensity, even mass, low possibility of agglomeration and flexile nutrient control.