The invention relates to a power drive device of a high-power semiconductor laser. The device comprises a switch power module, a wave filter, a semiconductor laser, a protection unit, a sensor, a PI adjuster and a potentiometer. The power drive device is characterized in that commercial electricity enters the power module through the wave filter; the anode and the cathode of the power module areconnected with the anode and the cathode of the semiconductor laser respectively; and the control end of the power module is connected with the output end of the adjuster. The in-phase input end and the anti-phase input end of the adjuster are connected with the potentiometer and the sensor respectively; and the protection unit and the semiconductor laser are in parallel connection. The power drive device has novel conception, a compact structure, small size, convenient mounting, good controlling performance and easy industrialized batch production, and can be widely used in occasions needingto provide a drive power for the semiconductor laser in the photoelectric field.