The invention provides a circular keyhole control system of an intelligent keyhole machine and belongs to the technical field of automatic control. The circular keyhole control system solves the technical problems that the prior structure has unreasonable design, unhigh automation degree, inconvenient use and the like. The control system comprises a needle control unit, a pressure pin control unit, a trimming control unit, a cloth feeding plate control unit, a wire clamping control unit, a cloth cutter control unit and a control center; a setting unit for presetting the running track of a needle is arranged between the control center and the needle control unit; the setting unit comprises a plurality of buttonhole stitch sequence units; and the buttonhole stitch sequence unit comprises an invoker which can invoke any of buttonhole stitch data in an invoking database or cite other buttonhole stitch sequence units. The circular keyhole control system can process the buttonhole stitches with different shapes, sizes and distances, can select single and combined buttonhole stitch data, has more flexible and diversified combined modes, convenient use and high intelligence degree, and can edit the database.