The invention discloses a medicine for treating anxiety neurosis. Tuckahoe , rhizima ligustici, rhizoma cyperi, semen zizyphi spinosae, rhizoma coptis, cinnamon, prepared rehmannia root, radix polygalae, mother-of-pearl, keel, carapax amydae and liquorice are used as raw materials; based on different characteristics of the traditional Chinese medicines, the traditional Chinese medicines in proportion are subjected to decoction, filtering, bottling and sterilization to prepare decoction by a routine method. The medicine is a traditional Chinese medicine preparation; according to a formula of traditional Chinese medicine theory, the medicine has reasonable material selection, tranquilizes, replenishes qi and addresses both the symptoms and root causes; and through the clinical observation of patients for many years, the medicine has remarkable curative effect for patients with anxiety neurosis caused by various reasons.