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CN101401961B 明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料的制备方法 失效 - 权利终止 转让

明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料的制备方法
摘要：
本发明提供了一种制备具有均一分布颗粒直径的明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料及其制备方法和装置。本发明制备的明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料：在颗粒本体内部含有大量的互通微孔，这种颗粒具有较高的比表面积，有利于细胞的粘附的组织液的流动；明胶-壳聚糖-羟基磷灰石复合球形多孔颗粒具有均一的粒径分布，不需要筛分处理即可得到具有相同粒径的颗粒材料因为根据本方法制备的明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料的粒径均一性好，而相同粒径的球形颗粒材料，充填后颗粒间空隙率最大，所以本发明的明胶-壳聚糖-羟基磷灰石球形多孔颗粒材料充填后有利于组织液的流动和细胞的迁移生长。
摘要（英）：

The invention provides a gelatin-chitosan-hydroxyapatite spherical porous particle material with homogeneous particle diameter distribution, and a method and a device for preparing the same. The gelatin-chitosan-hydroxyapatite spherical porous particle material prepared by the method contains a large number of micropores communicated with one another in a particle body, has higher specific surface area, and is advantageous to the flow of tissue fluid for adhering cells; the gelatin-chitosan-hydroxyapatite spherical porous particle has homogeneous particle diameter distribution, and particle materials of the same particle diameter can be obtained without screening treatment; and because the particle diameter of the gelatin-chitosan-hydroxyapatite spherical porous particle material prepared by the method has good uniformity and the spherical particle materials with the same particle diameter can obtain the largest inter-particle porosity after filling, gelatin-chitosan-hydroxyapatite spherical porous particle material is advantageous to the flow of the tissue fluid and the migration and the growth of the cells.

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