The invention provides a medicine preparation for clearing away heat and toxic material, which is composed of following Chinese traditional medicine materials: radix isatidis, chrysanthemum, mulberry leaf, mint, moutan bark, Chinese thorowax root, reed rhizome, cicada ecdysis, taraxacum, gypsum, dried orange peel, leaf of common perilla, cassia seed, rice, magnolia officinalis, figwort, Chinese wolfberry, rhizoma anemarrhenae, forsythia, liquorice, selfheal, gardenia and radix sileris; according to Chinese broad and wide traditional medicine theory and finely selected more than 20 Chinese traditional medicines and made through repeated clinical experiments, the medicine has the curative effects of heat-clearing and fire-purging and removing toxin for detumescence; and the medicine is usedfor swelling and pain in throat, swelling and pain in gum, constipation, fever heat, thirst, abdominal distention and red tongue caused by inner heat; thus having fine social effects and economical benefits through popularizing widely.