Disclosed is a medicine combination used for the treatment of osteoporosis induced by inadequate qi, kidney deficiency and blood stasis; the raw herbal materials includes radix astragali preparate, epimedium herb, twotooth achyranthes root, motherwort herb, fructus cnidii, rhubarb processed with wine; the medicine combination is applicable to the treatment of osteoporosis induced byinadequate qi, kidney deficiency and blood stasis; the symptoms appear as the followings: waist-ridge aching, weakness in waist and knees, weakness and tiredness in mind and physical body, incapability of long-time standing and walking due to bone pain, palpitation, spontaneous perspiration, breathless in movement, limbs numbness, moving the shortness of breath, numbness in limbs, dark red tongueor ecchymosis, slow or uneven pulse. The medicine combination has the efficacies of nourishing qi, supplementing kidney, promoting blood circulation, removing stasis and dredging collaterals, and has the advantages of less ingredients, great medical potency, safety and effectiveness and being made into various oral preparations.