The invention provides a high resolution video conference system and a method. A plurality of usable digital signals are compressed as a plurality of compressed digital signals by the high resolution video conference system through that the encoding module of a first terminal device is under the high-resolution compression standard; furthermore, the compressed digital signal is transmitted to a second terminal device by an instant transmission application software. A second terminal device decompresses the compressed digital signals under the high-resolution compression standard by an encoding module so as to gain a plurality of image signals; furthermore, the image signals are displayed by a display module. Therefore, the high resolution video conference system of the invention can realize the application of the high resolution video conference even under limited hardware efficacy and network transmission frequency width.