An anti-fake method with graded encryption is provided, which belongs to the technical field for the configuration of product anti-fake label. The invention is characterized in that: the invention comprises the following procedures: pressing and printing a main anti-fake bar on an invoice and other objects to be configured with the anti-fake label; the data of the main anti-fake bar is acquired by encrypting a serial consisting of number, letter, Chinese character or other two-digit data via an ordinary encryption method; the anti-fake bar is a concealed bar; using a reading device to read the main anti-fake bar on the object that is configured with the anti-fake bar; re-encrypting the data read from the main anti-fake bar with an encryption algorithm; encoding the encrypted data into an auxiliary anti-fake code and attaching the auxiliary anti-fake code to the object to be configured with anti-fake label. Therefore, the invention can add new code information to the original anti-fake label at any time during the circulation of the object configured with the anti-fake label, thus reducing the possibility of counterfeit, enhancing the anti-identification capability of the anti-fake label and realizing excellent anti-fake effect.