The invention discloses a drainage-tube with high negative pressure and zero accumulation, which comprises a built-in tube (1), a drug feeding pot (2), a drug feeding catheter (3) and a drainage external nozzle (5); the wall of the built-in tube is provided with side outlets (6) used for drainage; the rear end of the built-in tube is sheathed with the front connector of the drug feeding pot and communicated with the drainage external nozzle which is sheathed with the rear connector of the drug feeding pot; a tubulose net sleeve or a long-rectangular net piece (11) which is made from soft netty materials runs through the built-in tube; the front end of the tubulose net sleeve, after going through the front end of the built-in tube or the side outlet (15) of the tubulose net sleeve positioned at the front end of the built-in tube, is folded inversely to sheathe on all side outlets; the rear end of the tubulose net sleeve or the long-rectangular net piece is inducted in the drug feeding pot and then sealed and fixed; an inner tube (14) provided with side outlets used for draining on the tube wall and the tubulose net sleeve or the long-rectangular net piece are positioned in and run through the built-in tube in parallel; the rear end of the inner tube is connected to the internal connector of the rear part of the drug feeding pot and communicated directly with the drainage external nozzle that is sheathed with the external connector of the rear end of the drug feeding pot. The drainage-tube is not easily blocked and can adopt higher negative pressure drainage, and the net sleeve can be pulled out from the connector of the drug feeding pot.