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发明授权
CN101293917B 与PKR激酶结构域特异性结合的多肽及其应用 失效 - 权利终止

与PKR激酶结构域特异性结合的多肽及其应用
摘要：
一种能够与PKR激酶结构域特异性结合的多肽及其应用。本发明涉及PKR激酶结构域(PKRcat)的抑制12肽序列，其氨基酸序列为：Ser-Val-His-Leu-Tyr-His-Ser-Thr-Lys-Thr-Leu-Arg。本发明应用噬菌体展示文库，筛选能够与PKRcat特异性结合的12肽，该12肽具有与PKRcat特异性结合的特性，并且能够抑制其激酶活性。因此，该12肽对研究PKRcat在细胞调亡中的作用及PKRcat抑制剂的开发具有实用价值。
摘要（英）：

The invention relates to a polypeptide capable of specifically binding with the structural domain of PKR kinase and an application thereof. The invention relates to a 12-peptide sequence with amino acid sequence of Ser-Val-His-Leu-Tyr-His-Ser-Thr-Lys-Thr-Leu-Arg, which is capable of specifically binding with the PKR kinase structural domain (PKRcat) and inhibiting the activity of the PKR kinase. Therefore, the 12-peptide has practical value in research on the role of PKRcat in cell apoptosis and development of PKRcat inhibitors.

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