The invention provides a manufacturing method of metal nanometer particles with a hollow structure. Firstly, a first metal solution is added with an appropriate reducer so as to reduce a first metal ion to a first metal nanometer particle; a second metal solution with higher reduced potential than the first metal is added after the reducer is decomposed; due to the electrochemical redox reaction, the first metal particle is oxidized from the outside into the first metal ion when the second metal is reduced, thus obtaining a second metal nanometer particle in a hollow structure with high surface area. The manufacturing process is simple and the nanometer metal particle with even diameter and size can be obtained; according to different metals of the composition, the manufacturing method of the invention can be applied to catalyzing reaction of accelerant, material of sensing component, material of conductive membrane and so on, thus having industrial practical value.