The invention provides a sepiolite purification process, belonging to the sepiolite purification process, which mainly solves the technical problems that the existing process can not continuously produce the sepiolite with higher purity on a large scale, etc. The key point of the technical proposal is that crude ore mixed water is poured into a multi-class mixing pool and mixed with multi-class by a slow-speed mixing machine to prepare the slurry, settled with multi-class by an overflow settlement trough, and settled with multi-class by a buffer settlement pool and separated to prepare sepiolite suspension; solid and liquid separation of the sepiolite suspension is carried out by a screen filter device; dehydration by a press filter machine and the drying are carried out so as to gain the product. The sepiolite purification process is convenient for controlling the dispersion degree of the pulp and continuous production; the yield is greatly improved; the sepiolite purification process avoids the defect that the sepiolite is difficult to be separated from the water by the normal press filter machine; furthermore, no other filter aid is added, thus avoiding pulp pollution and greatly improving the dehydration speed. As the centrifuge is not adopted, the process can greatly reduce the energy consumption and increase the output. The sepiolite purification process can be widely applied to the processing and purification of various low-grade sepiolites.