The present invention presents an agent multivariate group setting method based on a simple network management protocol. The method is invented aiming at the low efficiency problem caused by that the prior art adopts setting the MIB base one by one. The method comprises the following steps: forming a data structure of simple network management protocol based management data base, grouping the variate in the message when the SNMP message is received, grouping the variates which have same living sample processing method to a group, and storing each group of variates in a chain table. The methodpresented by the invention can set the variates in a same group with a same living sample processing method. The efficiency for setting MIB base is greatly increased and the processing flow is shortened.