The invention provides a method of driving a plasma display panel. A plurality of discharge units are configured to the plasma display panel screen with a plurality of rows columns for displaying image frame including a plurality of subdomains. The method includes steps as follows: during at least one subdomains addressing period, an odd row or an even row and adjacent odd or even row are used asdisplay unit for processing addressing; then, during at least one subdomains display period, the display period is divided into tow, in one of the divided display period, only one side of two adjacent units in the display unit is utilized for displaying, and another of the divided display period, both side of two adjacent units are used for displaying.