The invention comprises a catalyst compound of formula Zr(L)(A1)(A2)(A3) where L represents a ketoamide ligand, A1, A2 and A3 may be the same or different and each represents a ligand derived from a compound selected from the group consisting of: an alcohol, a polyol, an alkyl acetoacetate, a diketone, a ketoamide, a carboxylic acid or ester thereof, an alkanolamine, a phosphoric acidester and a sulphonic acid or ester thereof. The compound may be made by the reaction of a zirconium alkoxide or haloalkoxide with a ketoamide. The compound is useful as a catalyst for the reaction of a polyisocyanate with a hydroxyl-containing compound, e.g. for the manufacture of polyurethanes or composite cellulosic materials such as fibre-boards.