The invention discloses a novel packaging device for an organic electroluminescent device, comprising a cover plate, a locating plate and a packaging holding apparatus, wherein, a groove which corresponds to a substrate is arranged on the cover plate and the substrate contact face of the organic electroluminescent device; hygroscopic agents are arranged inside the groove; the locating plate is provided with a locating hole the size of which is consistent with that of the substrate and arranged above the cover plate; the side face of the substrate which is provided with an organic electroluminescent layer faces towards and passes through the locating hole and is led into the groove; the packaging holding apparatus is arranged above the substrate which is closely connected with the cover plate. The packaging device of the invention can solve substrate slippage and deviation due to unequal stress during the packaging process, thereby packaging precision is guaranteed; packaging efficiency is improved; equipment requirements and production cost are reduced. Particularly, the invention has strong maneuverability on packaging of small and medium-sized substrates and large-sized cover plates and meets actual requirements.