The invention provides a multi-channel signal processing system, a multi-channel signal processing chip, a method thereof, a manufacturing method thereof, a filtering device, an external signal processing card and a signal transmitting and receiving device. The multi-channel signal processing system comprises a filtering unit which is arranged on a signal transmitting end and a feedback unit which is arranged on a signal receiving end; the filtering unit comprises a signal synthesis unit and a filter, and the signal synthesis unit inputs a signal waiting for transmission; wherein, the filter is used for filtering a crosstalk source signal of the signal waiting for transmission; the signal synthesis unit is used for synthesizing the signal waiting for transmission and the crosstalk source signal after filtering; the feedback unit feeds back according to the received signal waiting for transmission, wherein, the filter is also used for performing subsequent filtering according to information which is acquired by feedback. The invention can self-adaptively cancel a far end crosstalk signal.