The invention discloses a medicine combination used to cure or prevent malaria, which basically consists of arteannuin or derivatives thereof, naphthoquine and primaquine. The invention can be used in curing malignant malaria, quartan malaria and tertian malaria and is particularly suitable to cure malignant malaria with multi-drug resistance through adopting one dose therapeutics. The invention has good curative effect, less toxic and side effect and low cost, thereby being particularly suitable for fast control and elimination of malaria in various regions.