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Invention Publication
CN101044107A ( － ) －β －榄香烯 , ( － ) －β－榄香醛 , ( － ) －β －榄香醇,( － ) －β －氟化榄香烯及它们的类似物 ,中间产物和合成物的合成及应用 无效 - 驳回

( － ) －β －榄香烯 , ( － ) －β－榄香醛 , ( － ) －β －榄香醇,( － ) －β －氟化榄香烯及它们的类似物 ,中间产物和合成物的合成及应用
Abstract:
此发明为制备(－)－β－榄香烯，(－)－β－榄香醛，(－)－β－榄香醇，(－)－β－氟化榄香烯及它们的类似物提供了收敛过程，并且提供了对(－)－β－榄香烯制备非常有价值的中间产物。此外，本发明还得出了以(－)－β－榄香烯，(－)－β－榄香醛，(－)－β－榄香醇和(－)－β－氟化榄香烯为基础的新的合成物，并提出了针对脑肿瘤，肺癌，乳腺癌，前列腺癌，卵巢癌，结肠直肠癌，胃肠癌和胃癌的治疗方法。发明者建议针对癌症，尤其是对脑肿瘤，肺癌，卵巢癌，膀胱癌，子宫颈癌，结肠癌，乳腺癌和前列腺癌，使用联合疗法：(1)一种或多种抗癌药剂，包括(但并不只限于)顺铂，紫杉醇，紫杉醇衍生物和某种抗癌试剂；(2)一种或多种(－)－β－榄香烯及其类似物，包括(－)－β－榄香烯，(－)－β－榄香醛，(－)－β－榄香醇，(－)－β－氟化榄香烯及其类似物，以及(－)－β－榄香烯化学合成过程中的中间产物。
Abstract(English):

The present invention provides convergent processes for preparing (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, and (-)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (-)-beta-elemene. The present invention further provides novel compositions based on analogues of (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (-)-beta-elemene and its analogs, including (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride, and their analogs, and (-)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer, colon cancer, breast cancer, and prostate cancer.

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