The invention relates to method and device for inhibiting detonation propagation of combustible substance. The method includes pre-installing (in tunnels or walls) multiple vacuum chamber units having sealed ends facing the spaces where explosion might happen. The vacuum chamber units have inner surfaces coated with wave/energy absorbing layer, and have sealed ends provided with weak panels capable of being broken by environmental pressure variations. When explosion happens, the vacuum chamber receives the explosion shock; the weak panels are broken, expansion air, explosion shock and energy are absorbed by the vacuum chamber, as the chamber is negative pressure and vacuum, it can absorb the explosion shock and energy to inhibit maximatily the detonation propagation of the explosion shock and energy, thereby damage is reduced.