This invention relates to an application of styracine type curcumin analogs in resisting oxidation, and protecting liver and preventing brain damage. The compound has effects in protecting liver cells of suckling mouse from damage, promoting liver cells repair, scavenging superoxide anion and DPPH in vitro, inhibiting xanthine oxidase, protecting pheochromocytoma cell from damaging, and chelatingiron ion. Thus it is can be expected to be used for preparing medicine for preventing and treating chronic or acute liver or brain damage diseases, apoplexy, sequelae of apoplexy, Parkinson's disease, senile dementia, inflammation, autoimmune disease, tumour, myocardial ischemia, cardiac hypertrophy, senility, allergic response, and atherosclerosis.