This invention relates to an application of phenylpropionic acid styracine type and cinnamic acid styracine type curcumin analogs in resisting oxidation, and protecting liver and preventing brain damage. The compound has effects in protecting liver cells of suckling mouse from damage, promoting liver cells repair, scavenging superoxide anion and DPPH in vitro, inhibiting the generating activity of lipid peroxide, protecting pheochromocytoma cell simulating cranial nerve from damaging, and chelating iron ion. Thus it is can be expected to be used for preparing medicine for preventing and treating chronic or acute liver or brain damage diseases, apoplexy, sequelae of apoplexy, Parkinson's disease, senile dementia, inflammation, autoimmune disease, tumour, myocardial ischemia, cardiac hypertrophy, senility, allergic response, and atherosclerosis.